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Individuals living with obesity without preexisting cardiovascular disease who are receiving semaglutide for weight management and have achieved prior weight reduction of at least 10% with no further weight loss over past 12 weeks will be randomized to either gradual dose reduction over 16 weeks or abrupt treatment discontinuation
Semaglutide (Wegovy): Also initially for T2D (as Ozempic), semaglutide was approved for chronic weight management in adults who are obese or overweight
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PNPLA3 (rs738409, I148M) represents the strongest genetic signal for MAFLD/MASH, promoting hepatic lipid accumulation and inflammation ( For T2DM, risk is elevated by variants in TCF7L2, PPARG, SLC30A8, KCNJ11, and FTO
Acetyl L-carnitine slows decline in younger patients with Alzheimer's disease: a reanalysis of a double-blind, placebo-controlled study using the trilinear approach
