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Cornu R., Bduneau A., Martin H., 2022

Upon nerve injury, SARM1 undergoes a conformational change that activates its NADase activity, leading to the rapid depletion of NAD + 232

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The peptide is small enough (three amino acids plus a copper ion) to penetrate the stratum corneum, particularly when formulated with phospholipid-based delivery systems that enhance dermal absorption

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