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10.1093/pcp/pct201 Plant Cell Physiol
Enhanced Protocol: REDEFINE Clinical Titration The clinical trial program uses a structured 16-week titration to the full therapeutic dose: This clinical protocol is the evidence-based approach used in REDEFINE trials
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The first identified incretin was a gastric inhibitory peptide (GIP) with the activity of inhibiting the secretion of gastric acid, which was isolated from porcine small intestines ( + channel and depolarize the cell membrane, while also activate the voltage-dependent Ca 2+ channel, causing a Ca 2+ inflow and the generation of action potentials ( 2+ release by activating inositol triphosphate (IP3)
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