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These pathways regulate neurogenesis, angiogenesis (new blood vessel formation), myelination, dendrite development, axonal sprouting, and the integrity of the neurovascular unit the critical connection between brain cells and blood supply

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The key rationale for a universal vaccine approach is the continued burden of disease associated with endemic human coronaviruses (HCoVs), the unpredictability of future SARS-CoV-2 variants, and the potential for zoonotic spill-over events