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Synthetic hormone therapies (like injectable GH) can flood the body with unregulated hormone levels, potentially leading to side effects like joint pain, water retention, insulin resistance, or even suppression of your body's own GH production
Circadian Rhythm Regulation Khavinson, V.K
A 2020 review in Diabetes Care noted that "the hypoglycaemic effect of IGF-1 has been exploited therapeutically in rare forms of insulin-receptor-defect syndromes, but the risk-benefit calculation differs fundamentally from use in euglycaemic individuals" [20]
This in turn can have an impact on the development and progression of endocrine-related tumours which express receptors for GH, IGF, androgens and estrogens
3 Thyroidbrain axis pathophysiology and neurological manifestations The major mechanistic routes linking thyroid dysfunction to neuropsychiatric manifestations are summarized in Figure 2, highlighting disrupted hormone transport/activation in the brain, neurotransmitter imbalance, oxidative stressneuroinflammation, and bloodbrain barrier vulnerability
