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Online 51 , 105042 (2025)

Ruvolo P, Wang RY, Ruvolo V, Zeng Z, Qui YH, Pierce SA, McQueen T, Kornblau SM, Andreeff M

However, due to its non-selective suppression of the neddylation pathway, MLN4924 also promotes the accumulation of pro-tumorigenic factors such as PD-L1 (95), which can enhance cancer cell proliferation and immune evasion to some extent (96)

Pro-senescence neddylation inhibitor combined with a senescence-activated -galactosidase prodrug to selectively target cancer cells

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Besides reducing visceral fat, GH therapy may also lower cardiovascular risk