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Evidence-based alternatives include optimising nutrition with iron-rich foods and complex carbohydrates, taking recommended supplements such as vitamin D (10 micrograms daily), addressing iron deficiency if confirmed by blood tests, ensuring adequate hydration, and prioritising sleep when possible

This observation, together with the fact that 1 equivalent of DTT is not consumed in the reaction, indicated that intramolecular amide formation by nucleophilic attack of the AX side chain amino group to its electrophilic -lactam carbonyl, under these conditions, occurs only in the presence of DTT

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Higdon J, Drake VJ, Delage B, Crozier A (2023d) Flavonoids, Phytochemicals, Linus Pauling Institute, Oregon 2023, Accessed Nov 18, 2023