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Even when your appetite decreases, the body needs time to adjust to taking in fewer calories

Moreover, PHGDH upregulation confers resistance to MEK inhibitors in NRAS-mutant melanoma, whereas targeted PHGDH inhibition restores the sensitivity of resistant tumors to MAPK signaling pathway inhibitors by reducing intracellular glutathione levels and enhancing oxidative stress (89, 90)

Cancer Cell 2 AnastasiouD.PoulogiannisG.AsaraJ

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Commentary: Gene-environment interplay in the context of genetics, epigenetics, and gene expression