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DO NOT use prescription appetite stimulants or high-calorie supplements for treatment of anorexia or cachexia (unexplained wasting) in older adults

Those who took tirzepatide lost a greater percentage of body weight each month, compared to semaglutide: an average of 5.9% of their body weight after 3 months

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Peripherally administered liraglutide has recently been shown to gain access into certain areas of the brain with the majority entering the ARC and median eminence with smaller amounts in the PVN (Secher et al., 2014)