A high serum value can still carry clinical meaning even though there is no established upper intake limit for oral B12
Baltaci, B
In addition, the same receptor expressed in different cell types can be desensitized by different mechanisms
How N-3 PUFAs specifically affected neuronal survival, how key the specific time window is within which nutrients are supplemented and whether other nutrients or the combination thereof might also modulate adult hippocampal neurogenesis in the context of ES remains to be determined
In certain instances, once exposure to an active agent (e.g., concentration in the endolymph or perilymph) reaches steady state, the concentration of an active agent in the endolymph or perilymph stays at or about the therapeutic dose for an extended period of time (e.g., one day, 2 days, 3 days, 4 days, 5 days, 6 days, 1 week, 3 weeks, 6 weeks, or 2 months)
Furthermore, challenges such as low drug concentration at the local pathological site after systemic administration, limited target specificity and short drug half-life persist [6]
