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This is also significant

PlexusDx's Precision Peptide Genetic Test examines 14 peptide pathways including GLP1R rs6923761, which directly influences semaglutide receptor sensitivity, plus FTO and MC4R variants that affect overall metabolic rate

12 Treating Obesity-Related Comorbidities GLP-1 agonists show promise in treating NAFLD, a condition commonly seen in adolescents with obesity

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Glucagon increases your blood sugar level and prevents it from dropping too low, whereas insulin decreases blood sugar levels

This is not a random finding it's consistent with the biphasic response documented in the 2007 Pyo study