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The following reconstitution guidance reflects standard laboratory practices and is intended for qualified research personnel only

It is not for human or animal consumption, and no medical, therapeutic, or dosing claims are made

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The added targets generally correlate with larger weight reductions in trials

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An estimate of the final policy that includes the effects of estimated changes in enrollment, utilization, and case-mix based on the FY 2026 Mid-Session review budget approximates the estimated decrease in total payments at $290 million, with Medicare OPPS payments decreasing by $220 million and beneficiary copayments decreasing by $70 million in CY 2026