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These optimistic clinical outcomes were validated in individuals with concurrent IBS-D, stress, and depression by a randomized controlled study (RCT) (262)

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AHK-Cu may also reduce the secretion of transforming growth factor-beta1 by dermal fibroblasts

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Therefore, the homocysteine level may not rise enough to the abnormal range in a person with Down syndrome with a decrease in vitamin B12 or folate activity