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The glutathione biosynthesis pathway activity was decreased in the livers of HFD-fed mice

In comparison to ferroptosis-resistant cells, cells sensitive to ferroptosis accompanied by RAS mutation exhibit elevated TFR1 expression and reduced ferritin expression, indicating that higher iron import and lower iron storage may lead to ferroptosis (Yang and Stockwell, 2008)

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They must pass through cell membranes

It has also been shown that intranasal insulin improved memory and executive function in clinical settings [56, 57]