For the treatment regimen estimand, all tirzepatide doses were associated with numerically higher odds of participants with prediabetes achieving reversal versus liraglutide and semaglutide (Supplementary Material Table S8), although the higher proportion of patients with prediabetes achieving reversal in the placebo arm of SURMOUNT-1 compared with SCALE and STEP 1 suggests that the relative efficacy of tirzepatide versus liraglutide and semaglutide may be underestimated (Supplementary Material Table S4)
Toxicol Appl Pharmacol 268:7989 Yang X, Greenhaw J, Shi Q, Su Z, Qian F, Davis K, Mendrick DL, Salminen WF (2012a) Identification of urinary microRNA profiles in rats that may diagnose hepatotoxicity
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If a compounded product contains peptide fragments, impurities, aggregates, degradation products, or an incompletely characterised active ingredient, the immune system may recognise parts of that product as foreign
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