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Neuroprotective effect of Lentivirus-Mediated FGF21 gene delivery in experimental Alzheimers disease is augmented when concerted with Rapamycin

We acknowledge OpenEye/Cadence for providing us with an academic license for the software used in these studies

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The outcomes of this study should be used with caution if patients have co-morbidities that may affect efficacy

Additionally, emerging evidence from small cohort studies has identified liver-type fatty acid-binding protein 1 (FABP1) as a potential biomarker for AD pathology

This natural organelle replacement therapy directly supplies healthy mitochondria to functionally compromised cells, thereby restoring cellular ATP generation capacity at the root, reducing mtROS levels, and decreasing the release of pro-inflammatory factors (e.g., IL-1, IL-18)