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Unfortunately, the direct use protein neurotrophic factors as therapeutic agents has at least two serious limitations: 1 ) their large size and hydrophilic character preclude blood- brain barrier permeability (BBB)

Consistent with our observations in yeast, the difference in NADPH occupancy suggests a close match of the response ranges of both sensor variants with the physiological NADP redox state ( Figure S8 ), which may be estimated at about 0.3

The mean changes from baseline of Hb A 1c at d 28, and d 56 were: 0.16% 0.07 (1.71 mmol/mol) and 0.21% 0.09 (2.24 mmol/mol) for the ARA 290 group and 0.01% 0.07 (0.14 mmol/mol) and +0.21% 0.08 (+2.24 mmol/mol) for the placebo groups respectively (Figure 1

Cell Calcium 70, 2431

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In another study, cisplatin and ifosfamide-induced renal toxicity can be antagonized by silymarin without reducing anti-tumor efficacy of these drugs (6, 44-45)