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Additionally, indole-3-carboxylic acid (ICA), a metabolite derived from Lactobacillus gallinarum , has been shown to improve anti-PD-1 efficacy in mouse models with different microsatellite instability (MSI) statuses [104]

They illustrated that increases in total glutathione in the plasma were found in those individuals who already had higher circulating levels, which they suggested was a greater adaptive response to the damaging exercise bout[16]

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