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Furthermore, the lower systemic levels of bile salts prompt the liver to produce more bile, which in turn feeds more TGR5 agonism into the colon (343)

Numerous clinical studies have reported that the administration of L-carnitine (LC) and/or acetyl-L-carnitine (ALC) alleviates some effects of PCOS resulting in an increase reproductive outcome [73, 74, 75, 76, 77]