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Similar to how GLP-1s (glucagon-like peptide-1 agonists), such as Ozempic, suppress appetite and trigger weight loss, peptides can signal other functions, like the release of growth hormones

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GHK-Cu has similar cosmetic study data demonstrating improvements in skin thickness, collagen content, and elasticity

Plant Cell 21:34503458 Gao X, Yuan HM, Hu YQ, Li J, Lu YT (2014) Mutation of Arabidopsis CATALASE2 results in hyponastic leaves by changes of auxin levels

Expression of glycosaminoglycans and small proteoglycans in wounds: modulation by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+

As you can see on the far right, the agonist is bound to the receptor, however, this does not result in the channel opening