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A systematic review and network meta-analysis found that GLP-1RAs, while reducing total weight and fat mass, led to a decrease in lean body mass (mean difference 0.86 kg), with the loss accounting for approximately 25% of the total weight loss [14]

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Off-label use simply means a provider is using a substance for a purpose other than its original intention, based on professional judgment and clinical evidence

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The medication should appear clear and colourless to slightly yellow when properly stored