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Discovery of Novel, Potent, Brain-Permeable, and Orally Efficacious Positive Allosteric Modulator of 7 Nicotinic Acetylcholine Receptor [4-(5-(4-Chlorophenyl)-4-methyl-2-propionylthiophen-3-yl)benzenesulfonamide]: Structure-Activity Relationship and Preclinical Characterization

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Researchers commonly investigate MOTS-c in controlled laboratory studies involving mitochondrial-to-nuclear communication, metabolic flexibility, cellular adaptation mechanisms, and energy homeostasis pathway modelling