Studies suggest the prevalence of deficiency in the UK is one in 10 people aged 75 and over, one in 20 aged 65-74, and lower in younger age groups except for vegans, where prevalence is around 11%
in diet-induced obese mice, 5-Amino-1-MQ significantly reduces total body weight, fat mass, and adipocyte size, while improving insulin sensitivity and glucose tolerance 2,3
By contrast, vitamin B12 has prescription dosing schedules for deficiency
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In states of obesity and metabolic dysfunction, NNMT is often overexpressed in adipose tissue, depleting nicotinamide and reducing NAD+ availability [2]
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