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Melanotan-2: Broad Activation MT-2 activates all five melanocortin receptor subtypes : MC1R Melanin production (tanning) MC3R Energy homeostasis, sexual arousal MC4R Appetite regulation, sexual function, erectile response MC5R Sebaceous gland function This non-selective binding is why MT-2 produces tanning AND sexual effects AND appetite suppression AND nausea it's hitting every melanocortin pathway at once

10.1210/en.2014-1722 19 CappelliC.RotondiM.PirolaI.AgostiB.FormentiA.ZarraE.et al (2012)

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