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Am J Transl Res

Consistent with the transcriptomic prediction, the GLP-1R agonist (GLP-1RA) exendin-4 (0.1,1, and 2 g/kg body weight) reduced food intake in both WT and Bbs5 / fasted mice (Figure 4, K and L) in a dose-dependent manner (Figure 4, M and N)

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45 Currently, the strategy of multiple receptor stimulation is actively expanding indications in metabolic disorders, particularly in MASLD, and some medications have reported more potent therapeutic efficacy compared to single GLP-1RA