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The transition between medications is typically straightforward: finish semaglutide, wait about a week, then start tirzepatide at a low dose

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If you are already taking glucose-lowering medications such as metformin, insulin, or sulfonylureas, discuss it with your doctor to reduce the risk of hypoglycemia

Understanding this timeline helps set realistic expectations and supports treatment adherence during the early weeks of therapy

[DOI] [PubMed] [Google Scholar] 10.Prescott LF