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It was later approved for weight loss after researchers found that it helped control appetite and slow digestion

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63 In addition to their benefits on quality of life in HFpEF, further randomised trials are needed to effectively assess the effects of GLP-1 RA on harder clinical outcomes

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Furthermore, the effect of VMH leptin infusion on muscle glucose uptake is dependent on melanocortin signaling because melanocortin antagonists blocked the response to leptin (Toda et al., 2009)

Further studies are needed to explore the bidirectional relationship between sleep quality, NRF2 activation, and symptom improvement in FM