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While you can use sterile water for a single, immediate use where the entire vial is consumed, we strongly advise against it for multi-dose protocols

The data suggested that collagen type I synthesis, the predominant form of collagen in connective tissues, rose substantially under the influence of the peptide complex, in some cases reaching several times the baseline production level

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Histologically, epidermal thickening, severe hyperkeratosis, and epidermal acanthosis were seen (de Juanes et al., 2009)