L-2-Hydroxyglutarate sensitizes ferroptosis through ATF3/CHAC1-mediated glutathione degradation in hepatocellular carcinoma
Lack of robust human clinical trials prevents confirmation of consistent outcomes, optimal dosing, or long-term safety
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These involuntary excitations further exacerbate Na + influx, increasing the burden on the already compromised Na + /K + -ATPase, creating a potential vicious cycle of membrane depolarization and ion pump failure (83)
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