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REDEFINE 1 (Phase 3a, NEJM 2025) Garvey et al., n=3,417, 68 weeks
IDH1 mutations cause significant changes in enzymatic reactions, catalyzing the large-scale conversion of -ketoglutarate (2-KG) to 2-hydroxyglutarate (2-HG), and cause significant changes in the cells metabolic system
Inflammation and immune dysfunction in Parkinson disease
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Glutathione and IV Therapy: A Powerful Combination Combining IV therapy with glutathione can amplify the detoxification process and significantly boost the bodys defenses against oxidative stress
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