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Isenovic, University of Belgrade, Serbia The article belongs to the special issue Reactive Oxygen Species (ROS) in Pathophysiological Conditions The redox status in pathogenesis is critically regulated by careful balance between the generation of reactive oxygen species (ROS) and their elimination

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293 Furthermore, metabolic adaptations in CSCs, including a shift toward OXPHOS and FAO, enable them to sustain energy production even under low-nutrient conditions, increasing their resistance to glycolysis-targeting therapies