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MNS-DOX and DNS-DOX were converted by MGST1 and GSTP1-1 via sulfonamide cleavage into the active parent drug (Fig

However, when the 5-HT-releasing agent D-fenfluramine is used in patients experiencing a neurobehavioral syndrome after exposure to organophosphates, elevated sensitivity of central 5-HT receptors is observed (442)

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Open microchannels increase absorption 10-fold