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CKD, chronic kidney disease Introduction The spectrum of heart failure encompasses distinct categories, such as heart failure with a reduced ejection fraction (HFrEF), heart failure with mildly reduced ejection fraction (HFmrEF), and heart failure with preserved ejection fraction (HFpEF)

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Concurrently, stress-induced cytoskeletal contraction widens paracellular spaces and compromises junctional cohesion