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Some of the coenzyme Q derivatives, such as idebenone or vatiquinone (EPI-743), have been tested with various models and even subjected to human clinical trials of neurodegenerative diseases, and they seem to have only limited benefit (Gutzmann et al., 2002

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developed a novel DON prodrug, HDON, which can selectively activate nitroreductase in hypoxic tumor environments without affecting oxygen-rich normal tissues, showing significant tumor inhibition in the H22 mouse liver cancer model (Zheng et al., 2024)