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The STEP-1 trial demonstrated 14.9% mean body weight reduction at 68 weeks on 2.4mg weekly semaglutide

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High-dose oral supplements (often 10002000 micrograms daily) or intramuscular injections (typically 1mg hydroxocobalamin) used to treat pernicious anaemia or deficiency states can temporarily elevate serum levels

The risk has been estimated from 5-10% over a patients lifetime