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For constipation management , NICE Clinical Knowledge Summary guidance suggests a stepwise approach: first optimising fluid and fibre intake (introduced gradually to avoid worsening bloating), then considering appropriate laxatives based on stool consistency

Even without stimulants, high-dose B12 can cause jitteriness, palpitations, or insomnia, worsening anxiety symptoms

Proglucagon is a large precursor hormone molecule produced in the pancreas (alpha cells) and the intestines

Mar 2006;19(1):46-52

Without microbiota, even the development of myeloid cells in bone marrow is delayed

This reduces the risk of developing a rash at the injection site