Second endpoints in REDEFINE 1 showed full benefits beyond weight loss
What this means for overall gut health overall gut health Potential positives: Less glycemic volatility (fewer glucose-driven GI symptoms in some with diabetes) Reduced reflux triggers for some if weight loss decreases intra-abdominal pressure Improved MASLD/MASH biomarkers via weight loss and metabolic effects Lower overall intake may calm visceral hypersensitivity in some IBS-D cases Potential challenges: Delayed emptying early fullness, nausea, reflux, or vomiting if portions/fats are too high Constipation in those with slow motility or low fiber/fluid intake Gallstones with rapid loss Undernutrition may contribute to overall symptoms and inflammation impacting the gut Poor balance of meals due to low intake may negatively impact the gut microbiome Rare but serious pancreatitis or ileus requiring immediate care The bottom line is that these medications arent 100% good or 100% bad
Talk With a Clinician Curious whether an NAD and resveratrol experiment fits your goals or whether a targeted skin protocol would deliver more value
Intramuscular injections deliver medication directly into muscle tissue
Ultimately, this results in the modulation of the sleeps architecture and optimization of the various stages of sleep, especially the highly restorative slow-wave sleep (SWS), often referred to as deep sleep or stage 3 sleep [1, 2]
Tripathi SS, Singh S, Garg G, Kumar R, Verma AK, Singh AK, Bissoyi A, Rizvi SI
