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Thus, while GLP-1 RAs like semaglutide are widely recognized for their metabolic benefits, their role in neuroprotection remains uncertain

For adverse events that lead to discontinuation its 4 per 100 patient years

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Specifically, thiamine is important for glucose metabolism [51] and type 2 diabetics have been observed to have lower-than-average thiamine levels, suggesting that some degree of thiamine deficiency may play a role in the onset of diabetes