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270 Thus, the relationship among PS1 gene mutations or deficiencies, lysosomal acidification, and lysosomal calcium ion dysregulation warrants further investigation

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Often theyre molecules that might have shown really early promise in a scientific study, Malins from the ANU says

Int J Mol Med 36(5):13691376 Yang S, Zhang X, Zhang H, Lin X, Chen X, Zhang Y et al (2021) Dimethyl itaconate inhibits LPS-induced microglia inflammation and inflammasome-mediated pyroptosis via inducing autophagy and regulating the Nrf-2/HO-1 signaling pathway

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