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The aromatic head groups of shikonin form a interaction with H41 on the S2 subsite

The results were evaluated by calculating the risk ratio (RR), mean difference (MD), and confidence interval (CI)

The construct possessing alpha gem -dimethyl groups on the maytansinoid side (DM4) and one methyl group on the antibody side was as stable as the non-cleavable linker, MCC-DM1 (27)

This indicates that oral GLP-1 medications can be a viable option for individuals struggling with obesity