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Monoamine contents The supernatants of the homogenised brain sample were mixed with 1 M sodium acetate to adjust the pH to 3.0 and injected into an HPLC system equipped with a reversed-phase ODS column and electrochemical detector

It doesn't seem to just patch up one problem

Agriculture (Basel)

However, test-tube and animal studies show that guarana extract may boost metabolism and limit fat cell production by suppressing certain genes ( Side effects: Because guarana is high in caffeine, it may cause insomnia, headaches, nervousness and increased heart rate and anxiety, especially when taken in high doses ( Summary Guarana which is especially high in caffeine may boost metabolism, but more research is needed to determine whether it suppresses appetite or promotes weight loss

Liu et al., 2020

These reactive oxygen species, in turn, activate lipid peroxidation, a key step leading to ferroptosis