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doi: 10.3389/fpls.2024.1373801 Received 20 January 2024 Accepted 23 February 2024 Published 12 March 2024 Volume 15 - 2024 Edited by Ahmed Abdelkhalek, City of Scientific Research and Technological Applications, Egypt Reviewed by Nuria Montes, Hospital Universitario de La Princesa, Spain Updates Copyright 2024 Kozie, Otulak-Kozie and Rusin

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Contraindications Do Not Use If You Have a known hypersensitivity to cobalt or any ingredient in the formulation (rare) Have Lebers disease (hereditary optic nerve atrophy) cyanocobalamin can cause rapid optic nerve atrophy Warnings and Precautions Hypokalemia (low potassium): May occur during initial treatment of severe megaloblastic anemia