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Low GSH, neutrophil infiltration, myeloperoxidase activity and inflammation increase oxidative stress overwhelming the antioxidant defense, and hypochlorous acid mediated GSH oxidation and its attachment to proteins contribute to further GSH deficiency (114)

5.2 Pathway-Specific Approaches in Genetic PD GBA1-variant associated PD is the most common genetic PD subtype and overall has an earlier age of onset, faster progression and greater risk for cognitive decline as well as generally greater NMS burden [190]

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Lixisenatide showed disease-modifying effects in the LIXIPARK trial by stabilizing motor symptoms in early PD [36]

doi: 10.1128/JB.00851-07 279 SchmitterT.PilsS.WeibelS.AgererF.PetersonL.BuntruA.et al