Patients who are on GLP-1 medications and stop them generally regain a substantial amount of the weight that they lost.
Liraglutide follows a similar proteolytic cleavage pathway in various tissues, akin to the metabolism of other large proteins
GLP-1 Support Protein: Formulated with 30 g of whey protein, 5 g of collagen for skin health and myHMB (TSI Group) and PeptiStrong (Nuritas) to help counteract muscle loss
Patients on diabetes medications (metformin, sulfonylureas, or insulin) should discuss combination inositol-semaglutide therapy with their healthcare provider to ensure appropriate dose adjustments
Anecdotally, some people who switched from semaglutide to tirzepatide report that their appetite, which had started returning somewhat on semaglutide, decreased again on tirzepatide
This Special Feature discusses the challenges associated with assessing changes in muscle mass that accompany GLP-1 drug-induced weight loss, the potential impact of muscle mass loss, and how to preserve muscle mass