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supplements of selenium of 200 g/d (as selenium yeast or selenomethionine), generally considered to be safe, have been associated with toxic effects (alopecia, dermatitis, squamous cell carcinoma, type-2 diabetes mellitus, high-grade prostate cancer) in North Americans ( Reference Lippman, Klein and Goodman 106 Reference Stranges, Marshall and Natarajan 108 )

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Cholinesterase inhibitors (donepezil, rivastigmine) - Theoretical complementary mechanisms cholinesterase inhibitors increase acetylcholine while dihexa builds new synapses