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Cortisol Both peptides stimulate the HPA axis through CRF-mediated ACTH release (ACTH releasing activity of KP-102, 2005): Ghigo et al

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This requires careful selection of populations who are most likely to benefit, such as older adults with low serum 25(OH)D levels, sedentary lifestyles, or mild cognitive impairment, as well as standardized intervention protocols that allow clearer interpretation