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Squeezing it too hard can cause it to regurgitate more pathogen-carrying saliva

doi: 10.1093/ageing/afy169

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Asterholm IW, Mundy DI, Weng J, Anderson RG, Scherer PE (2012) Altered mitochondrial function and metabolic inflexibility associated with loss of caveolin-1

In particular, the improvement of therapeutic half-life 5 through incorporation of non-natural amino acids, D-amino acids, PEGylation, N- and C-terminal modifications, and attachment on the side chains has afforded an extended therapeutic window of activity in vivo , leading to dosing regimens that are comparable to those of small molecules

On top of that, the bottle price is only part of the equation