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Comparison across biofluids further highlighted both opportunity and constraint: while lumbar and ventricular CSF showed strong concordance, plasma profiles diverged substantially, particularly for immune-active pathways such as kynurenine metabolism 67 , indicating that treatment-relevant metabolic states are most directly captured in CSF and only partially reflected in peripheral blood

WT samples for each peptide-spectra match by dividing each TMT reporter ion intensity by the average intensity for the channels corresponding to WT control (3 per TMT sample)

WTZ, ZGO, LN and JJZ: Conceptualization, Data curation, Formal analysis, Methodology, Investigation, Software, Writing-original draft, and Writing-Review & Editing

The shedding typically lasts 2 to 4 weeks and signals positive response

Increases in muscle strength ranged from 24-62% depending on the muscle group