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This mechanism also promotes osmotic diuresis, which helps lower blood pressure by approximately 4/2 mmHg and reduces fluid retentionproviding direct kidney benefits and kidney protection for patients with chronic kidney disease

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After ingestion of a meal, GLP-1 is secreted by intestinal L cells and acts on a cognate receptor within the pancreas to stimulate insulin release, while neuronal pathways also contribute to GLP-1s insulinotropic actions

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While these medications commonly cause gastrointestinal side effects such as nausea and constipation, back pain is not listed as a characteristic adverse effect in FDA prescribing information