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Neither is supported by strong evidence.52 Surgery is a last resort treatment for refractory cases of patellar tendonitis,53 when all non-surgical options have been exhausted and the patient fully understands the risks and benefits of the respective procedure.54 It requires a longer rehab time of 6 to 12 months,55 but the long-term results are promising.56 For example, in one study surgery improved symptoms in 57% of patients.57 However, for non-recalcitrant cases of patellar tendonitis an exercise-based approach is a far superior option58 and performed correctly, it can produce outstanding results

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Potential role of neuroactive tryptophan metabolites in central fatigue: establishment of the fatigue circuit

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Melatonin improves mitochondrial function by preventing mitochondrial fission in cadmium-induced rat proximal tubular cell injury via SIRT1-PGC-1 pathway activation